JOPSS - Search Results

Journal Articles

Medical application of radiohalogenated peptides; Synthesis and evaluation of F(- $^{131}$ I)KCCYSL for targeting HER2

Sasaki, Ichiro; Watanabe, Shigeki; Ohshima, Yasuhiro; Sugo, Yumi; Yamada, Keiichi*; Hanaoka, Hirofumi*; Ishioka, Noriko

Peptide Science 2015, p.243 - 246, 2016/03

Journal Articles

A Combination use of boron and gadolinium compounds in NCT trial

Zhang, T.*; Matsumura, Akira*; Yamamoto, Tetsuya*; Yoshida, Fumiyo*; Sakurai, Yoshinori*; Kumada, Hiroaki; Yamamoto, Kazuyoshi; Nose, Tadao*

Research and Development in Neutron Capture Therapy, p.819 - 824, 2002/09

From present study, the irradiation effect by using combination of Boron and Gd, showed various irradiation effects (additive effect, less than additive effect, non additive effect), which depend on Gd concentration. The additive effect will be occurred when using a combination of Gd and Boron with low concentration, however, adding Gd to high concentration will reduce additive effect resulting in less than additive to finally non-additive effect. This result indicate that achieving suitable concentrations of Gd and Boron together in tumors may increase the therapy effect, but achieving excess concentration of Gd with Boron together in tumor may cause negative therapeuitic effect.

JAEA Reports

biological effectiveness of JRR-4 epithermal neutron beam; Experiment under free air beam and in water phantom (Cooperative research)

Yamamoto, Tetsuya*; Yamamoto, Kazuyoshi; Matsumura, Akira*; Kumada, Hiroaki; Kishi, Toshiaki; Hori, Naohiko; Torii, Yoshiya; Horiguchi, Yoji; Nose, Tadao*

JAERI-Research 2002-011, 56 Pages, 2002/05

JAERI-Research-2002-011.pdf:3.17MB

The surviving curve and RBE of dose components generated in boron neutron capture therapy (BNCT) were separately determined in neutron beams at JRR-4. Surviving fraction of V79 cell with or without $_{10}$ B was obtained using an epithermal neutron beam (ENB), a mixed thermal-epithermal neutron beam (TNB-1), and a thermal neutron beam(TNB-2), which were used or planned to use for clinical trial. The cell killing effect of these beams depended highly on the neutron beam used, according to the epithermal and fast neutron content in the beam. RBE of the boron capture were 3.990.24, 3.040.19 and 1.430.08, RBE of the high-LET dose components based were 2.500.32, 2.340.30 and 2.170.28 for ENB, TNB-1 and TNB-2, respectively. The experimental determination of biological effectiveness factor outlined in this paper is applicable to the dose calculation for each dose component of the neutron beams and contribute to an accurate RBE as comparison with a neutron beam at a different facility employed in ongoing and planned BNCT clinical trials.

JAEA Reports

Radiation induced transformation; Article review

Saigusa, Shin*

JAERI-Review 2002-009, 43 Pages, 2002/03

JAERI-Review-2002-009.pdf:2.3MB

The mechanism of the process of radiation-induced transformation that leads normal mammalian cell to malignant feature is still not clear. However, a drastic development of molecular biological technique in medical biology research field since 1990's have progressively revealed the mechanisms of this process and recent results have been starting to incorporate in the recent radiation risk estimate procedures. This report describes the results of the survey and review of the articles concerned with experimental studies of radiation induced in vitro transformation, since 1993 to 1997.

JAEA Reports

Evaluation of JRR-4 neutron beam using tomor cells (Cooperative research)

Yamamoto, Kazuyoshi; Yamamoto, Tetsuya*; Kumada, Hiroaki; Torii, Yoshiya; Kishi, Toshiaki; Matsumura, Akira*; Nose, Tadao*; Horiguchi, Yoji

JAERI-Tech 2001-017, 38 Pages, 2001/03

JAERI-Tech-2001-017.pdf:2.5MB

no abstracts in English

Journal Articles

Rotating irradiation system for in vitro BNCT experiments at JRR-4

Matsushita, Akira*; Yamamoto, Tetsuya*; Matsumura, Akira*; Shibata, Yasushi*; Nose, Tadao*; Yamamoto, Kazuyoshi; Kumada, Hiroaki; Hori, Naohiko; Torii, Yoshiya

Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.203 - 204, 2000/10

no abstracts in English

JAEA Reports

Pu(IV) Nitrate crystallization behavior confirmation experiment

*; *; *; *

JNC TJ8400 2000-061, 92 Pages, 2000/03

JNC-TJ8400-2000-061.pdf:8.79MB

Crystallization procedure is considered to have an advantage in recovering rather pure uranium from contaminated uranium solution and to be applicable for a new reprocessing process. It was confirmed until last year that the reprocessing process with crystallization procedure has a sufficient advantage. But the data for Pu crystallization is very rare. although it is necessary for design of the process with crystallization procedure. In this study, a beaker scale plutonium test was performed in AEA Technology Harwell Laboratory to confirm a behavior of Pu (IV) nitrate under crystallization condition. The results were examined by Mitsubishi Materials Corporation. Test item was a measurement of temperature in case of Pu (IV) nitrate crystallization or freezing of the solution in the following six parameters. (Pu(g/L):200, 100, 50, HNO $_{3}$ (m):6, Pu valence:4). (Pu(g/L):200, 100, 50, HNO $_{3}$ (m):4, Pu valence:4). Test results were as follows. (1)Pu(IV) nitrate crystallization was not observed even in the case 200g Pu/L and HNO $_{3}$ 6M and 4M which were considered to the best condition but crystal of H $_{2}$ O and HNO $_{3}$ 3H $_{2}$ O were observed. (2)Similar results were obtained for the other parameter with lower Pu concentration. (3)We can estimate that Pu(IV) nitrate crystallization will not occurred in the reprocessing process with crystallization procedure. (4)The solubility data of Pu(NO $_{3}$ ) $_{4}$ - HNO $_{3}$ -H $_{2}$ O system was obtained.

Journal Articles

Biodegradable poly(DL-lactic acid) formulations in a calcitonin delivery system

Asano, Masaharu; Yoshida, Masaru; Omichi, Hideki; Mashimo, Toru*; Okabe, Kazuhiko*; Yuasa, Hisako*; Yamanaka, Hidetoshi*; Morimoto, Seiki*; Sakakibara, Hideo*

Biomaterials, 14(10), p.797 - 799, 1993/08